Jul 03, 2016
Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model
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Gut pathogens (2016)

Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model

Publication Type  Journal Article
 Authors George TetzVictor Tetz
 Abstract Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. The role of microbiota in increased intestinal permeability is under intensive investigation. Here, we studied alterations in the host and increased intestinal permeability as a direct effect of treatment with a bacteriophage cocktail. After 10 days of challenge, the rats showed weight loss, messy hair, and decreased activity. Additionally, they displayed a significantly elevated lactulose:mannitol ratio and the level of circulating immune complexes. To our knowledge, this study demonstrates for the first time that increased intestinal permeability may be induced by bacteriophages that affect the microbiota.

Year of
Publication
2016
 Journal Gut pathogens
 DOI 10.1186/s13099-016-0109-1
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